Normal Range Calculation:Manual Puocessing of the Data which Conlain Abnoumal Data
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概要
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A manual calculation method of the normal range from the data which contain a certain number of abnormal data was presented. The data are summarized in a frequency table, and the classes with the frequency less than one fifth of the maximum frequency are eliminated (initial truncation). Cumulative sum of the remaining classes is calculated (truncated cumulative sum), and 24.4 percentile (X<SUB>24</SUB>) and 75.6 percentile (X<SUB>76</SUB>) arecalculated from the truncated cumuiative sum. The lower limit (R<SUB>L</SUB>) and the upper limit R<SUB>U</SUB>of the normal range are calculated as follows: d=x<SUB>76</SUB>-x<SUB>24</SUB>, R<SUB>L</SUB>=x<SUB>24</SUB>-d, R<SUB>U</SUB>=x<SUB>76</SUB>+d. Classes with the class mark less than RL and those with the class mark larger than RU are eliminated from the original frequency table, and the remaining classes are subjected to repeated calculations as described above, until R<SUB>L</SUB> and R<SUB>U</SUB> give constant values. This method was extended to the log-normal distribution processing without log calculation. The only difference from the normal distribution processing as described above is R<SUB>L</SUB> and R<SUB>U</SUB> calculation, which are calculated as follows: r=x<SUB>76</SUB>/x<SUB>24</SUB>, RL=x<SUB>24</SUB>/r, R<SUB>U</SUB>=x<SUB>76</SUB> r. The calculated range was less affected by contamination of abnormal data up to 20 per cent.
- Japan Society of Clinical Chemistryの論文
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