Serum Uric Acid and Hypertension

概要

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Hyperuricemia occurs frequently in essential hypertension. We analysed influences of hypertension and ageing on serum uric acid and serum creatinine by epidemiological study of 805 women and 528 men over 40 years old in Hakushucho, Yamanashi Prefecture. Normotensive subjects (n=635), borderline hypertension (n=330) and established hypertension (n=368) were classified by WHO criteria of hypertension. Serum uric acid increased slightly along with ageing in all groups (but insignificantly). On the contrary, a significant correlation was demonstrated between serum uric acid and ageing in normotensive subjects and borderline hypertension. But no significant correlation was found in established hypertension. Serum uric acid concentration in established hypertension was the highest of all groups and its concentration in borderline hypertension was higher than those of normotensive subjects. Positive correlation was observed between serum uric acid and serum creatinine in all groups. These data suggest that hyperuricemia in hypertension is associated with the height of the blood pressure and renal involvement.
Japanese Society of Gout and Nucleic Acid Metabolismの論文