Two Cases of Stevens-Johnson Syndrome

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Stevens-Johnson syndrome (SJS) is a potentially fatal disorder characterized by high fever, widespread blistering exanthema with mucosal involvement and is characterized by sudden apoptosis of keratinocytes leading to erosion of the mucos membrane. Epidermal detachment of the less than 10% of the total body surface area is typical within this spectrum of epidermal necrolysis. SJS is associated with lifethreatening dermatological conditions that are characterized by mucosits erosions. The underlying etiology is almost invariably secondary to drugs. We report herein on two cases of SJS associated with carbamazepin and allopurinol. A 76-year-old man with dyspnea was admitted to our hospital. He was diagnosed as having SJS due to carbamazepin which he had taken 1 month previously. A 75-year-old woman with a sore throat was admitted to our hospital. She was diagnosed as having SJS due to allopurinol which she had taken 3 weeks previously. We advised clinicains to pay careful attention to the fact that SJS has various symptoms. It is necessary for us to confirm which medicine the patients had previously taken.