Left Ventricular Improvement after Cardiac Resynchronization Therapy among Ischemic, Non-Ischemic and Right Ventricular Pacing-Induced Cardiomyopathy
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概要
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<B>Background:</B> The difference in the effect of cardiac resynchronization therapy (CRT) in patients with non-ischemic cardiomiopathy (NICM) and RV pacing-induced cardiomyopathy (PACING) hasn’t been fully estimated. <B>Methods and Results:</B> We investigated the effect of CRT between 6 to 12 months after implantation of ischemic cardiomyopathy (ICM), NICM and Pacing group. LV end-systolic diameter (ESD) on echocardiography and serum BNP level before and after CRT implantation were evaluated. Fourty patients (ICM: 9 patients, NICM: 22 patients, PACING: 9 Patients) were implanted CRT-P or CRT-D between January 2006 to September 2010. CRT-P was implanted in 14 patients and CRT-D was in 26 patients. At baseline, ESD and BNP level showed no significant differences among 3 groups. On follow-up periods, ESD and BNP level didn’t change in ICM group (ESD: from 62.3±6.7 to 58.3±7.5 mm, BNP: from 530.9±388.0 to 496.4±280.0 ng/ml, both p=NS). In NICM group, BNP level was significantly decreased but ESD was not (ESD: from 54.3±9.8 to 53.5±10.5 mm, p=NS, BNP: from 583.2±406.6 to 339.7±238.7 ng/ml, p<0.05). In PACING group, ESD and BNP level was significantly decreased (ESD: from 51.2±8.6 to 47.7±9.1 mm, BNP: from 859.6±669.2 to 290.1±421.2 ng/ml, both p<0.05). The change of ESD (δESD) was no significant differences among 3 groups, but the change of BNP (δBNP) was significantly difference in PACING group compared to other groups (both p<0.05). No patients died within 12 months after CRT implantation. <B>Conclusion:</B> RV pacing-induced cardiomyopathy showed significant improvement compared with ICM and NICM group in serum BNP level.
著者
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Takeuchi Ryosuke
Department of Cardiology, Shizuoka City Hospital
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Onodera Tomoya
Department Of Cardiology Shizuoka City Hospital
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Takizawa Akinori
Department Of Cardiology Shizuoka City Hospital
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Sakamoto Atsushi
Department Of Cardiology Central Hospital Of Jnr.
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Nawada Ryuzo
Department Of Cardiology Shizuoka General Hospital
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Nakai Masanao
Department Of Cardiovascular Surgery Shizuoka City Hospital
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Murata Koichiro
Department of Cardiology, Shizuoka City Hospital
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Kurabe Takashi
Department Of Cardiology Shizuoka City Shizuoka Hospital
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Hosoya Natsuko
Department of Cardiology, Shizuoka City Shizuoka Hospital
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Kageyama Shigetaka
Department of Cardiology, Shizuoka City Shizuoka Hospital
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Takahashi Kosuke
Department of Cardiology, Shizuoka City Shizuoka Hospital
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Kazihara Jun
Department of Cardiology, Shizuoka City Shizuoka Hospital
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Nakai Masanao
Department of Cardiosurgery, Shizuoka City Shizuoka Hospital
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