Visualization of Intra-QRS Fragmented Activation in Patients with Hypertrophic Cardiomyopathy (HCM) and Life-Threatening Ventricular Arrhythmias Using Magnetocardiography (MCG)
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概要
- 論文の詳細を見る
Several studies indicated that intra-QRS fragmentation (QRSf) on ECG is a possible marker of lethal ventricular arrhythmias, however, the origin remains unclarified. We hypothesized that patients with hypertrophic cardiomyopathy (HCM) who experienced ventricular arrhythmia exhibit similar abnormalities, which can be visualized by magnetocardiography (MCG). <B>Methods:</B> In 21 HCM patients with a history of VT (n=11) and Vf (n=10), necessitating ICD subsequently, we examined the presence of QRSf on ECG and analyzed QRS current arrow mapping by using a 64-Ch MCG system. We measured left ventricular conduction time. Healthy volunteers (n=25) served as Controls. <B>Results:</B> In 19 of 21 patients, QRSf was present on ECG. MCG analysis revealed that LV conduction time in HCM patients was markedly prolonged. In 15 of 19 patients, during the period corresponding to QRSf, we recognized abnormal, complicated current patterns. <B>Conclusions:</B> HCM patients with a history of VT/Vf often showed QRSf on ECG, which is noninvasively visualized on the MCG 2-D current arrow maps.
著者
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Aiba Takeshi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Noda Takashi
Department of Cardiology, National Cardiovascular Center
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Satomi Kazuhiro
Department Of Arrhythmia And Electrophysiology National Cerebral And Cardiovascular Center
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Kamakura Shiro
Department Of Cardiology National Cardiovascular Center
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Shimizu Wataru
Department Of Biotechnology Faculty Of Engineering Nagoya University
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Okamura Hideo
Department Of Cardiology Japan Red Cross Wakayama Medical Center
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Yamada Yuko
Department Of Cardiovascular Medicine Osaka National Hospital
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Hashimoto Shuji
Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University
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Sugimachi Masaru
Department Of Artificial Organ Medicine Division Of Surgical Medicine Osaka University Graduate Scho
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Takaki Hiroshi
Department of Agriculture and Forest Science, Faculty of Agriculture, Miyazaki University
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Noda Takashi
Department of Cardiology, National Cerebral and Cardiovascular Center
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Aihara Naohiko
Department of Cardiology, National Cerebral and Cardiovascular Center
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Sakane Kazushi
Department of Cardiology, National Cerebral and Cardiovascular Center
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Yamada Yuko
Department of Cardiology, National Cerebral and Cardiovascular Center
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Aiba Takeshi
Department of Cardiology, National Cerebral and Cardiovascular Center
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Sugimachi Masaru
Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute
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Okamura Hideo
Department of Cardiology, National Cerebral and Cardiovascular Center
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Hashimoto Shuji
Department of Cardiology, National Cerebral and Cardiovascular Center
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