Mechanism and New Findings in Brugada Syndrome(Mechanisms and Future Challenge)
スポンサーリンク
概要
- 論文の詳細を見る
Brugada syndrome is a clinical entity characterized by coved type ST-segment elevation in the right precordial electrocardiographic leads (Vi-s) and an episode of ventricular fibrillation in the absence of structural heart disease. Although a number of clinical and experimental reports have elucidated the electrocardiographic, electro-physiologic, cellular, and molecular aspects, several problems remain unsolved. Recently developed high-resolution optical mapping techniques in arterially-perfused wedge preparations enable recording of transmembrane action potentials from 256 sites simultaneously at the epicardial surface, thus providing further advances in the understanding of the cellular mechanism of the specific ST-segment elevation and subsequent ventricular arrhythmias. In this review article, new findings relating to several unresolved problems such as gender difference (male predominance) and ethnic difference (higher incidence in Asian population) are also presented.
- 社団法人日本循環器学会の論文
- 2007-06-20
著者
-
Shimizu Wataru
Division of Cardiology, National Cardiovascular Center
-
Kamakura Shiro
Division of Cardiology, National Cardiovascular Center
-
Shirao K
Department Of Cardiovascular Surgery National Cardiovascular Center
-
Aiba Takeshi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
-
Ashihara Takashi
Department Of Cardiovascular And Respiratory Medicine Heart Rhythm Center Shiga University Of Medica
-
Ashihara Takashi
Department Of Cardiovascular Medicine Shiga University Of Medical Science
-
Shirao Kuniaki
国立医薬品食品衛生研究所
-
Arafune Tatsuhiko
National Inst. Of Advanced Industrial Sci. And Technol.
-
Arafune T
Graduate School Of Frontier Sciences The University Of Tokyo
-
Arafune Tatsuhiko
Inst. For Human Sci. & Biomed. Eng. National Inst. Of Advanced Industrial Science And Tech.
-
Aiba Takeshi
Division Of Cardiology Johns Hopkins University School Of Medicine
-
Shimizu Wataru
Division Of Arrhythmia And Electrophysiology Department Of Cardiology National Cerebral And Cardiova
-
Aiba Takeshi
Division Of Arrhythmia And Electrophysiology Department Of Cardiology National Cerebral And Cardiova
-
Kamakura Shiro
Division Of Cardiology Department Of Internal Medicine National Cardiovascular Center
-
Kamakura Shiro
Division Of Arrhythmia And Electrophysiology Department Of Cardiovascular Medicine National Cerebral
-
Aiba Takeshi
Department Of Cardiovasculardynamics National Cardiovascular Center
関連論文
- Diagnostic Value of the Recovery Time-Course of ST Slope on Exercise ECG in Discriminating False-From True-Positive ST-Segment Depressions
- PJ-002 Demonstration of Electrical Connection between Left Atrium and Musculature of Coronary Sinus in Human(Arrhythmia, Diagnosis/Pathophysiology/EPS 3 (A) : PJ1)(Poster Session (Japanese))
- PE-108 Histologic Variation within the Koch's Triangle : Histologic Study Relevant to Atrioventricular Nodal Reentrant Tachycardia(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting of The J
- Clinical Impact of Genetic Studies in Lethal Inherited Cardiac Arrhythmias(SPECIAL ARTICLE FOR THE 2008 SATO AWARD)
- Predictors of Electrical Storm in Patients With Idiopathic Dilated Cardiomyopathy : – How to Stratify the Risk of Electrical Storm –
- FRS-031 Additional Gene Modifiers Reduce Effectiveness of β-blockers in the Long QT Type 1 Syndrome(Arrhythmia-Basic : Molecular and Genetic : Basis (A) : FRS4)(Featured Research Session (English))
- QRS Prolongation is Associated With High Defibrillation Thresholds During Cardioverter-Defibrillator Implantations in Patients With Hypertrophic Cardiomyopathy
- Ischemia Induced Conduction Delay Plays a Key Role in Predisposing the Heart to Ventricular Fibrillation (Arrhythmia, Basic 5 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Steep Repolarization Gradient in the Epicardium Develops Phase-2 Reentry and Subsequent Ventricular Tachyarrhythmias in a Model of the Brugada Syndrome(Arrhythmia, Basic 3 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-504 Sodium Channel Block with Pilsicainide Accentuates the Arrhythmogenic Substrate in a Model of the Brugada Syndrome(Arrhythmia, Basic 6 (A) : PJ84)(Poster Session (Japanese))
- FRS-149 Mutation Site-Specific Differences in Arrhythmic Risk and Sensitivity to Sympathetic Stimulation in Japanese Families with Congenital LQT1 Syndrome(Sudden Cardiac Death (A) : FRS18)(Featured Research Session (English))
- 5 Genotype- and Mutation site-Specific Differences in Arrhythmic Risk and Sensitivity to Sympathetic Stimulation in the Long QT Syndrome(APSC/JCS Joint Symposium (APSC) (H) : Emerging Issue in Cardiology for Asian)(Special Program)
- Sympathetic Stimulation Produces a Greater Increase in Both Transmural and Spatial Dispersion of Repolarization in LQT1 Than LQT2 Forms of Congenital Long QT Syndrome
- Sudden Death in a patient With Apparent Idiopathic Ventricular Tachycardia
- Electrophysiologic Changes in Arrhythmogenic Substrate Following the Maze Procedure in Patients With Lone and Paroxysmal Atrial Fibrillation
- Diagnostic and prognostic value of a Type 1 Brugada electrocardiogram at higher (third or second) V_1 to V_2 recording in men with Brugada syndrome
- LQT1, but not LQT2, patients show an exercise-induced increase in transmural dispersion of repolarization (TDR)
- PJ-284 Efficacy of Radiofrequency Catheter Ablation for Supraventricular Tachycardia in Patients with Pulmonary Hypertension(Arrhythmia, diagnosis/pathophysiology/EPS-14, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-104 Severer Phenotypes of Long QT Syndrome are Associated with Compound Mutations : A Multicenter Study(PE018,Arrhythmia, Others (Clinical/Pathophysiology) (A),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Soci
- FRS-118 Seasonal Pattern of Occurrence of Cardiac Events in Genotyped Patients with Congenital Long QT Syndrome(FRS24,Novel Mechanisms of Ventricular Arrhythmia (A),Featured Research Session (English),The 73rd Annual Scientific Meeting of The Japanese Cir
- Mutation Site Dependent Variability of Cardiac Events in Japanese LQT2 Form of Congenital Long-QT Syndrome
- PJ-591 Histologic Reconstruction of the Postero-inferior Atrioventricular Septal Junction : With Reference to Autopsy Finding of Atrioventricular Reentrant Tachycardia(Arrhythmia, diagnosis/Pathophysiology/EPS(15)(A),Poster Session(Japanese),The 72nd Annu
- 3 Mutant KCNE3 Reduces Repolarizing Potassium Current And Causes Long QT Syndrome(Plenary Session 4 (PL-4) (A) New Scientific Approaches to QT Prolongation,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-297 Clinical and Electrocardiographic Characteristics, Pharmacological Response, and Therapy in Patients with Short QT Syndrome Associated with Cardiac Events(PJ050,Arrhythmia, Others (Clinical/Diagnosis/Treatment) 4 (A),Poster Session (Japanese),The 7
- PJ-087 Direct Comparison of the Filtering Effects between ICD Products(PJ015,ICD (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-486 Clinical and Electrocardiographic Characteristics and Clinical Course in Genotyped Patients with Congenital Long QT Syndrome Treated with Implantable Cardioverter Defibrillator(PE082,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) (A),Poster
- OE-283 How Long should Patients Refrain from Driving after Exchange of Implantable Cardioverter Defibrillator (ICD) Generator?(OE48,CRT (M),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- OE-258 Augmented ST-Segment Elevation at Exercise Testing can Predict Cardiac Events in Patients with Brugada Syndrome(OE44,Exercise Test/Cardiac Rehabilitation (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanese Circulation
- OE-154 Clinical and Electrocardiographic Characteristics in Relation to Ryanodine Receptor (RyR2) Gene Mutation in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia(OE26,Ventricular Arrhythmia (Clinical/Diagnosis/Treatment) (A),Oral Pres
- 1 Acquired Form of Brugada Syndrome(Proarrhythmic Risk of Drugs and Their Evaluation,Symposium 7 (SY-07) (I),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- Noninvasive Characterization of Intra-Atrial Reentrant Tachyarrhythmias After Surgical Repair of Congenital Heart Diseases(Arrhythmia/Electrophysiology)
- PE-583 Clinical Impact of Serum D-dimer on Excluding Atrial Thrombi(Thromboembolism/Antithrombotic therapy/Thrombolysis(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-068 Prevalence and Predictors of Electrical Storm in Patients with Implantable Cardioverter Defibrillator and Idiopathic Dilated Cardiomyopathy(Arrhythmia, therapy-06, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-108 Prognostic Impact of Type 1 Brugada ECG at Early Recovery Phase during Exercise Testing in Brugada Syndrome(Exercise test/Cardiac rehabilitation-5, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-482 Histologic Exploration of Coronary Sinus Muscularture on Atrioventricular Nodal Tissue(Arrhythmia, diagnosis/Pathophysiology/EPS(09)(A),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Genotype-Phenotype Correlation in the Congenital Long-QT Syndrome in a Single Center Study
- OJ-010 Clinical and Electrocardiographic Characteristics of Genotype-Unknown Patients with Congenital Long-QT Syndrome(Arrhythmia, diagnosis/pathophysiology/EPS-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OE-339 Ventricular Tachycardia Associated with Cardiac Sarcoidosis : Characteristics and Possibility of Catheter Ablation(Arrhythmia, Diagnosis/Pathophysiology/EPS 11 (A) : OE43)(Oral Presentation (English))
- Inappropriate therapy in dual chamber Implantable Cardioverter Defibrillator
- Ventricular fibrillation in Brugada syndrome is initiated by PVC with relatively prolonged coupling Interval
- PJ-557 Impact of Long-Term Use of β-blockers and/or Ca-antagonists in the Electrocardiogram and Clinical Course of Patients with Brugada Syndrome(Cardiovascular pharmacology, basic/clinical-5, The 71st Annual Scientific Meeting of the Japanese Circulation
- PE-158 Effects of Beta-Blocker on Dynamic Repolarization Measured by 24-hr Electrocardiography in LQT1 and LQT2 Forms of Congenital Long-QT Syndrome(ECG/Body surface potential mapping/Holter-5, The 71st Annual Scientific Meeting of the Japanese Circulatio
- OJ-066 Incidence and Characteristics of Inappropriate Therapies due to Atrial Fibrillation or Atrial Flutter in Patients with Implantable Cardioverter Defibrillator(Arrhythmia, therapy-06, The 71st Annual Scientific Meeting of the Japanese Circulation Soc
- OJ-008 Variety of Clinical Phenotype in Patients with the LQT3 Syndrome due to a Hot Spot Mutation, E1784K, in SCN5A Gene(Arrhythmia, diagnosis/pathophysiology/EPS-03, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Assessment of Ablitity of Halo Catheter to Diagnose Complete Isthmus Block Utilizing Electroanatomical Mapping System
- FRS-048 The Ablation Site of Ventricular Tachycardia Originated from Left Ventricular Outflow Tract(Novel Strategies for Arrhythmia(1)(A),Featured Research Session,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-213 Long-term Follow-up of Ventricular Tachycardia Associated with Cardiac Sarcoidosis(Arrhythmia, therapy-18, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 5 Cellular Mechanism, Gender and Ethnic Difference in the Brugada Syndrome(Symposium 5 (SY-05) (A) New Findings of Mechanism and Therapeutic Strategies of Idiopathic Ventricular Fibrillation,Special Program,The 72nd Annual Scientific Meeting of the Japane
- 2 Mutation Location- or Mutation Type-Specific Clinical Severity and Therapy in LQT1 and LQT2 Forms of Congenital Long-QT Syndrome(Plenary Session 4 (PL-4) (A) New Scientific Approaches to QT Prolongation,Special Program,The 72nd Annual Scientific Meeting
- FRS-041 Direct sequencing based on precise characterization of clinical phenotype is sufficient for genotyping of congenital Long QT syndrome(Arrhythmia-Clinical : Advances in Diagnosis and Management (A) : FRS5)(Featured Research Session (English))
- Epinephrine Test for Genotyping LQT1 and LQT2 Forms of Congenital Long QT Syndrome
- PJ-698 Restration of Normal Ventricular Activation Sequence Contributes for Positive Response to Cardiac Resynchronization Therapy in Chronic Heart Failure(ECG/Body surface potential mapping/Holter-7 (A) PJ117,Poster Session (Japanese),The 70th Anniversar
- PJ-644 Complete Right Bundle-branch Block as a Predictor of Long-term Mortality in Arrhythmogenic Right Ventricular Cardiomyopathy(Cardiomyopathy, basic/clinical-7 (M) PJ108,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the J
- PJ-451 Is Idiopathic Ventricular Tachycardia Originating from the Right Ventricular Outflow Tract Really Benign?(Arrhythmia, diagnosis/pathophysiology/EPS-11 (A) PJ76,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese
- PJ-049 Acute Hemodynamic Effects of Cardiac Resynchronization Therapy in Patients with Severe Chronic Heart Failure(Heart failure, clinical-17 (M) PJ9,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Soc
- FRS-012 Clinical Characteristics and Acute Management for Electrical Storm of Torsade de Pointes in Genotyped Patients with Congenital Long QT Syndrome(Clinical Arrhythmia-2 (A) FRS3,Featured Research Session,The 70th Anniversary Annual Scientific Meeting
- Practical Approach for Detecting Cardiac Sarcoidosis in Patients with AV Block(Arrhythmia, Diagnosis/Pathophysiology/EPS 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Electrophysiological Study as Prognostic Factor for Recurrence after Catheter Ablation for Post-operative Right Atrial Flutter(Arrhythmia, Diagnosis/Pathophysiology/EPS 4 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Long-Term Follow-up of Electrocardiographic Features in Patients with Brugada Syndrome : Comparison between SCN5A Mutation Carriers and Non-Mutation carriers(ECG/Body Surface Potential Mapping/Holter 2 (A), The 69th Annual Scientific Meeting of the Japane
- Clinical Significance of Body Surface Area of ST-segment Elevation in Patients with Brugada Syndrome(ECG/Body Surface Potential Mapping/Holter 2 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-258 Abnormal Current Distributions at Early Repolarization Phase Characterized by Magnetocardiogram in Patients with Brugada Syndrome(ECG/Body Surface Potential Mapping/Holter 3 (A) : OJ30)(Oral Presentation (Japanese))
- Spatial Repolarization Abnormalities Detected by Magnetocardiogram in LQT1 and LQT2 Forms of Congenital Long QT Syndrome
- Are Both Repolarization and Depolarization Abnormalities Localized in the Right Ventricular Outflow Tract in Brugada Syndrome?
- A New Index Combining Spatial and Transmural Dispersion of Repolarization in LQT1 Form of Congenital Long QT Syndrome
- Long-Term Efficacy of Empirical Chronic Amiodarone Therapy in Patients With Sustained Ventricular Tachyarrhythmia and Structural Heart Disease
- The Brugada Syndrome : An Update
- Genotype-phenotype correlation in the long QT syndrome : Genotype-specific response to sympathetic stimulation
- PJ-602 Clinical Characteristics Associated with Mutation Sites in LQT2 Form of Congenital Long-QT Syndrome(Arrhythmia, basic-5 (A) PJ101,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 5 Overlap Between LQT3 and Brugada Syndrome : Clinical Features in a Common Mutation and Underlying Biophysical Mechanisms(Plenary Session 4 (PL-4) (A) New Scientific Approaches to QT Prolongation,Special Program,The 72nd Annual Scientific Meeting of the
- Differential Effects of β-blockade on Dispersion of Repolarization in Absence and Presence of Sympathetic Stimulation Between LQT1 and LQT2 Syndrome
- FRS-030 High-Resolution Optical Mapping Reveals Cellular Mechanism of T-wave Alternans Preceding Ventricular Fibrillation in a Model of the Brugada Syndrome(Arrhythmia-Basic : Molecular and Genetic : Basis (A) : FRS4)(Featured Research Session (English))
- Transmural Heterogeneity of the Action Potential Configuration in the Feline Left Ventricle
- Optimal Management in the Long QT Syndrome(The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 6 Genetics of Inherited Cardiac Arrhythmias(States of Science and Art in Cardiovascular Medicine,Presidential Planning Program,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-134 Prediction of Symptomatic Hypotension after Maximal Exercise Using a Post-exercise Rapid, Excessive HR Decrease(Exercise Test/Cardiac Rehabilitation 3 (IHD) : PE23)(Poster Session (English))
- 2 Future Challenge in Brugada syndrome : Gender and Ethnic Differences(Brugada Syndrome:From Cell to Bedside,Plenary Session 2 (PL2) (A),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Testosterone Associated with Low Body Mass Index Contribute to Male Predominance in Brugada Syndrome(Arrhythmia, Diagnosis/Pathophysiology/EPS 9 (A), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- 3 Indication of CRT-D : How can we make a beneficial usage for CRT-D?(Indication for CRT-D, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Clinical Impact of Genetic Screening in Lethal Inherited Cardiac Arrhythmias(Japan Heart Foundation Satoh Memorial Award Lecture,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- -0272-ROLE OF EARLY AFTER DEPOLARIZATIONS IN THE GENESIS OF TORSADES DE POINTES IN PATIENTS WITH CONGENITAL LONG QT SYNDROME
- -118-EFFECTS OF COMBINATION THERAPY OF DISOPYRAMIDE AND MEXILETINE ON THE ANTEROGRADE CONDUCTION OVER THE ACCESSORY PATHWAY IN PATIENTS WITH WOLFF-PARKINSON-WHITE SYNDROME : Cardiovascular Drugs : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SC
- Electrophysiologic Study-Guided Amiodarone for Sustained Ventricular Tachyarrhythmias Associated With Structural Heart Diseases
- PJ-132 Clinical Characteristics and Prognostic Implications in Patients with High Defibrillation Thresholds(Arrhythmia, Non-Pharmacological Therapy 2 (A) : PJ22)(Poster Session (Japanese))
- Is predischarge electrophysiologic test necessary for the patients with Implantable Cardioveter Defibrillator?
- Clinical Effect of Implantable Cardioverter Defibrillator Replacements : When Should You Resume Driving After an Implantable Cardioverter Defibrillator Replacement?
- Predictors of Electrical Storm in Patients With Idiopathic Dilated Cardiomyopathy : How to Stratify the Risk of Electrical Storm
- Mechanism and New Findings in Brugada Syndrome(Mechanisms and Future Challenge)
- Cellular and Ionic Mechanism for Brugada Syndrome(Ion Channels and Cardiac Arrhythmias : Current Understanding and Future, The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-185 High-resolution Measurements of Exercise-induced U-wave Amplitude Changes can Accurately Localize Myocardial Ischemia(Exercise test/Cardiac rehabilitation-4 (IHD) PJ31,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the
- PE-027 Characteristics of Atrial Tachycardia Presenting Dual-Loop Reentry(Arrhythmia, Diagnosis/Pathophysiology/EPS 6 (A) : PE5)(Poster Session (English))
- OJ-424 Simple Indexes from the Twelve-Lead Electrocardiogram in Predicting the Origin of Ventricular Arrhythmias Arising from the Ventricular Outflow Tract(ECG/Body Surface Potential Mapping/Holter 6 (A) : OJ52)(Oral Presentation (Japanese))
- OJ-337 Ablation of Atrioventricular Nodal Reentrant Tachycardia of Uncommon Type with Eccentric Atrial Activation in Coronary Sinus(Arrhythmia, Non-Pharmacological Therapy 11 (A) : OJ41)(Oral Presentation (Japanese))
- OE-295 Steroid Therapy for Cardiac Sarcoidosis : Comparison between Patients with and without Steroid Therapy(Cardiomyopathy, Clinical 6 (M) : OE37)(Oral Presentation (English))
- OE-217 Endocardial Electroanatomical Substrate and Catheter Ablation in Patients with Nonischemic Cardiomyopathy and Monomorphic Ventricular Tachycardia(Arrhythmia, Non-Pharmacological Therapy 9 (A) : OE27)(Oral Presentation (English))
- OE-224 Assessments of Transversal Conduction Property of Crista Terminalis and Its Influence on Recognition of Isthmus Block Utilizing Electroanatomical Mapping System(Arrhythmia, Diagnosis/Pathophysiology/EPS 10 (A) : OE28)(Oral Presentation (English))
- Augmentation of ST-Segment Elevation at Early Recovery after Exercise Testing in Patients with Brugada Syndrome
- Initiating Mode of Torsade de Pointes in Patients with Congenital Long QT Syndrome
- Heart Rate Dynamics at the Onset of Ventricular Fibrillation as Retrieved from Implantable Cardioverter-Defibrillators in Patients with Brugada Syndrome
- FRS-150 Radiofrequency Catheter Ablation for Idiopathic Ventricular Fibrillation and Ventricular Tachycardia Initiated by Premature Extrasystoles Originating from Right Ventricular Outflow Tract(Sudden Cardiac Death (A) : FRS18)(Featured Research Session
- Atrioventricular Block-Induced Torsades de Pointes With Clinical and Molecular Backgrounds Similar to Congenital Long QT Syndrome