Magnetocardiography Can Predict Clinical Response and Long-Term Prognosis after Cardiac Resynchronization Therapy
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概要
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<B>Background:</B> Cardiac resynchronization therapy (CRT) is a treatment for heart failure (HF) with electromechanical dyssynchrony. However, there is no available tool to accurately predict the efficacy. We hypothesized that magnetocardiography (MCG) with high spatio-temporal resolution can predict the CRT response. <B>Methods:</B> We analyzed 64-ch MCGs in 25 patients with HF and QRS prolongation on ECG (18 CLBBB, 7 IVCD). According to the 2-D current mapping, they were divided into 2 groups (Group-A with Uni-directional pattern and Group-B with Multi-directional pattern). We compared clinical and echocardiographic characteristics at 6 months after CRT implantation. CRT responder was defined when >10% LVDd decrease or >10% LVEF increase was recognized. <B>Results:</B> There were no significant differences between the groups in baseline LVDd, LVEF, BNP, and NYHA. After 6 months, we found 12 responders out of 13 Group-A patients and 9 non-responders out of 12 Group-B patients (p=0.001). During the follow-up of 721±339 days, cardiac events occurred less frequently occurred in Group-A (only 1 HF hospitalization) vs. Group-B (1 death, 2 LVAS implant, 5 HF hospitalization). <B>Conclusions:</B> MCG can predict the CRT response and long-term prognosis after CRT.
著者
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Aihara Naohiko
Department Of Cardiovascular Medicine National Cardiovascular Center
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Aiba Takeshi
Department Of Cardiovascular And Respiratory Medicine Shiga University Of Medical Science
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Noda Takashi
Department of Cardiology, National Cardiovascular Center
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Satomi Kazuhiro
Department Of Arrhythmia And Electrophysiology National Cerebral And Cardiovascular Center
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Kamakura Shiro
Department Of Cardiology National Cardiovascular Center
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Shimizu Wataru
Department Of Biotechnology Faculty Of Engineering Nagoya University
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Okamura Hideo
Department Of Cardiology Japan Red Cross Wakayama Medical Center
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Yamada Yuko
Department Of Cardiovascular Medicine Osaka National Hospital
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Hashimoto Shuji
Department Of Applied Biological Chemistry Faculty Of Agriculture Niigata University
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Sugimachi Masaru
Department Of Artificial Organ Medicine Division Of Surgical Medicine Osaka University Graduate Scho
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KAMAKURA Shiro
Department of Cardiology, National Cerebral and Cardiovascular Center
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Takaki Hiroshi
Department of Agriculture and Forest Science, Faculty of Agriculture, Miyazaki University
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Usami Shunsuke
Department of Cardiology, National Cerebral and Cardiovascular Center
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Aihara Naohiko
Department of Cardiology, National Cerebral and Cardiovascular Center
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Yamada Yuko
Department of Cardiology, National Cerebral and Cardiovascular Center
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Aiba Takeshi
Department of Cardiology, National Cerebral and Cardiovascular Center
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Sugimachi Masaru
Department of Cardiology, National Cerebral and Cardiovascular Center Reserch Institute
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