Possible Mechanism of Secondary Narcolepsy with a Long Sleep Time Following Surgery for Craniopharyngioma
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概要
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A 19-year-old woman suffered from severe excessive daytime sleepiness accompanied with long sleep episodes both in the daytime and nighttime and frequent episodes of cataplexy shortly after the removal of craniopharyngioma in the intrasellar space. Multiple sleep latency test showed a typical finding of narcolepsy, and cerebrospinal fluid orexin concentration was below the narcolepsy cut-off value. MRI-tractography showed a clear lack of neuronal fiber connections from the hypothalamus to the frontal lobe. SPECT using 123I-IMP showed frontal hypoperfusion. These connection damages could have been responsible for the occurrence of narcolepsy-like symptoms and long daytime sleep episodes in this case.
著者
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Komada Yoko
Department Of Psychogeriatrics National Institute Of Mental Health National Center Of Neurology And
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Yamada Shozo
Department Of Hypothalamic And Pituitary Surgery Toranomon Hospital
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Inoue Yuichi
Department Of Biochemical Science And Technology Faculty Of Agriculture Kagoshima University
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Kanbayashi Takashi
Department Of Neuropsychiatry Akita University Graduate School Of Medicine
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Nakamura Masaki
Department Of Applied Physics Okayama University Of Science
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Kawana Fusae
Department Of Clinical Physiology Toranomon Hospital
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Kanbayashi Takashi
Department of Neuropsychiatry, Akita University School of Medicine, Japan
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Sakuta Keisuke
Department of Psychiatry, Tokyo Medical University, Japan
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