:articular Injection of Arteparon for Osteoarthrosis of the Knee Joint

概要

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In order to examine whether 50 mg mucopolysaccharide polysulfuric acid esters (MPS) is the optimal dose for osteoarthrosis of the knee, a . double blind comparative study was carried out. A total of 101 patients were divided into three groups ; 32 patients treated with 25mg MPS, 34 patients with 50 mg, 35 patients with 100 mg. Intra-articular injections were given five to ten times at about weekly intervals. No statistical difference between the three groups was noted in the degree and the incidence of side effects. The rates of usefulness were 53.1% in the 25 mg group, 67.6% in the 50 mg and 54.3% in the 100 mg, while there was no statistically significant difference among the three. An improvement of score is superior in the order of concentration. The effect of ten-times injection was superior to that of five. In conclusion, 50 mg MPS seems to be an appropriate therapeutic dose, and ten-times injection is recommended for osteoarthrosis of the knee.
一般社団法人日本臨床薬理学会の論文