The direct synthesis of methyl 2,4-di-O-benzyl-.ALPHA.-D-xylopyranoside by the regiospecific benzylation of methyl .ALPHA.-D-xylopyranoside.

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概要

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• The regiospecific benzylation of methyl α-D-xylopyranoside with benzyl chloride and sodium hydride produces methyl 2,4-di-<I>O</I>-benzyl-α-D-xylopyranoside in a 70% yield, together with the by-products, methyl 2,3- and 3,4-di-<I>O</I>-benzyl-α-D-xylopyranosides. The structure of the 2,4-di-<I>O</I>-benzyl derivative was confirmed through the alternative synthesis of the 2,3- and 3,4-di-<I>O</I>-benzyl derivatives <I>via</I> the <I>O</I>-isopropylidene and <I>O</I>-cyclohexylidene derivatives of methyl α-D-xylopyranoside.

• 公益社団法人 日本化学会の論文

著者

• Zen Shonosuke

  School Of Pharmaceutical Sciences Kitasato University

• Koto Shinkiti

  School Of Pharmaceutical Sciences Kitasato University

• Morishima Naohiko

  School Of Nursing Kitasato University

• Kusuhara Chiharu

  School of Pharmaceutical Sciences, Kitasato University

関連論文

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