Synthesis of lepiochlorin, a chlorinated antibiotic, by use of electrochemical haloalkoxylation.
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概要
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The fungal metabolite lepiochlorin was synthesized from 2-methyl-4-oxopentanoic acid by the electrochemical chloromethoxylation of 2-methyl-2,4-pentadien-4-olide in MeOH–NH<SUB>4</SUB>Cl–(Pt–Pt) system followed by hydrolysis in a mixed solution of dioxane–H<SUB>2</SUB>O–concd HCl (25/10/1 V/V/V) in 38% overall yield.
- 公益社団法人 日本化学会の論文
著者
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Torii Sigeru
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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Inokuchi Tsutomu
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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Kondo Kazumi
Department of Industrial Chemistry, School of Engineering, Okayama University
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