Detosylation of <I>N</I>-Tosyl Amino Acids and Peptides by Electrolytic Reduction
スポンサーリンク
概要
- 論文の詳細を見る
An electrolytic reductive cleavage of tosyl group in <I>N</I>-tosyl amino acids was carried out by the use of 2 mol equivalent of NaCl or KCl as an electrolyte to the tosyl amino acids and of lead as a cathode in methanol–water. The procedure was applicable to the cleavage of <I>N</I>-tosyl peptides with preservation of the peptide bond, and with retention of their optical activity. No cleavage of the other protecting groups such as urethane type group and benzyl group was observed. The optimum conditions for reductive cleavage were found to be pH 11, lead being preferable to other cathode metals.
- 公益社団法人 日本化学会の論文
著者
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Matsumoto Kazuo
Department Of Cardiology Saitama Medical School
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Takahashi Takeo
Department Of Anesthesiology Sapporo Medical College And Hospital
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MATSUOKA MANABU
DEPARTMENT OF MATHEMATICS (DOCTOR COURSE), NAGOYA UNIVERSITY
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Iwasaki Tameo
Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry Tanabe Seiyaku Co., Ltd.
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Matsuoka Manabu
Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry Tanabe Seiyaku Co., Ltd.
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Okumura Kentaro
Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry Tanabe Seiyaku Co., Ltd.
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Matsumoto Kazuo
Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry Tanabe Seiyaku Co., Ltd.
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