リゾチームのラット糖代謝におよぼす効果

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Lysozyme' known as anti-inflammatory drug, has been shown to decrease the fasting blood sugar level in chlorpropamide-treated diabetics in recent studies done in several clinics. In order to characterize the influence of lysozyme on carbohydrate metabolism, changes in blood sugar and plasma IRI levels after intraperitoneal injection of lysozyme in rat were investigated. Glucose uptake in peripheral tissues were simultaneously observed using the isolated rat diaphragm and epididymal fat pad.<BR>After a lysozyme injection of 10 or 25 mg/kg body weight, there were no changes in blood sugar and plasma IRI levels. But with dose of 50 or 100 mg/kg body weight, a significant decrease in blood sugar levels and a progressive elevation of plasma IRI levels was observed at 30, 60 and 120 min.<BR>Glucose uptake in the isolated rat diaphragm and epididymal fat pad was not increased when lysozyme was directly added to the medium. On the contrary, glucose uptake was significantly increased when the diaphragm and epididymal fat pad from rats preinjected lysozyme 30 min. prior to isolation of these tissues was used. Insulin effect on glucose uptake in both tissues was not influenced by lysozyme added to the medium or injected prior to isolation.<BR>Lysozyme elevates plasma IRI levels and accelerates glucose utilization in peripheral tissues and then lowers blood sugar levels. The above findings suggest that lysozyme produces a favorable internal environment for glucose uptake in rats.
日本内分泌学会の論文

リゾチームのラット糖代謝におよぼす効果

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