家兎VX-2子宮癌に対する化学塞栓療法の抗腫瘍効果についての実験的検討

概要

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Pharmacokinetics after Cisplatin (1mg/kg) therapy with transcatheter arterial embolization (TAE) by Gelfoam particles was studied in a rabbit uterine cancer model. It was prepared by transplantation of 5x107 of VX-2 carcinoma cells into the unilateral uterus. The pelvic lesions after two treatments, Cisplatin with TAE and Cisplatin by intraarterial infusion, were compared.<BR>The venous serum platinum clearance cur ves were similar for the both groups. However, A rapid early arterial serum clearance was observed for the IA group, but not for the TAE group. The tissue platinum concentration, [Pt], was measured in 80 minutes after treatments by atomic absorption spectrometry. [Pt] at the uterine tumors after TAE was 2.52 times higher than at the tumors after IA treatment (p < 0.01). In the chemoembolized pelvic metastatic lymph nodes [Pt] was 4.63 times as high as that for IA group(p < 0.01). These results indicate that TAE is an effective procedure for improvement in treatment of uterine cancer.
Kinki Brain Tumor Pathology Conferenceの論文