切除不能肝癌に対する温熱療法

概要

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45 cases of hepatic tumors (HCC cases: 23 cases, Metastic liver cancer: 22 cases) were treated by local hyperthermia combined with intraarterial chemotherapy. Hyperthermia was performed by 8 MHz RF capacitive heating device. Intra-arterial chemotherapy or chemoemblolization using DSM (Degradable Starch Micropheres) and lipiodol was combined with hyperthermia. Chemoterapeutic agents were 5-FU, ADM, MMC and/or CDDP. The mean Tmax was lower in the HCC group than in the metastatic group. However, even HCC cases, remarkable increases in tumor temperatures were obtained, when hyperthermia was combined with embolization materials. The risings of the temperature were greater in the cases with portal vein obstruction than wiothout it. The effective rates were 31.1% in all case,30.4% in HCC group, and 31.8% in metastatic tumor group. The response rate was fairly higher in the high tumor temperature group(over 42°C) than in the low termperature group(under 42°C). Toxities were not severe. This treatment was useful for advanced hepatic tumors.
Kinki Brain Tumor Pathology Conferenceの論文