Radiation damage of the salivary gland and effects of a radiation protective. Part 2 Histological observations in animal experiments.:-Part 2: Histological Observations in Animal Experiments-

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Histological observations were made on radiation damage of the parotid glands of rats. Changes in tissue occurred two days after exposure to various radiation doses, and specimens collected 1 and 2 weeks after radiation were observed with a light microscope and an electron microscope respectively. The observations were made in rats injected intraperitoneally with a radiation protectant (YM-08310, 200mg/kg) 30 minutes before radiation, and untreated controls.Light-microscopic observations showed vacuolar degeneration, agranulocytes, and celluar atrophy that became severer with higher radiation doses. Electron-microscopy revealed light bodies which were reported to be present soon after radiation. In the animals treated with YM-08310, the changes observed by light microscopy were found milder compared to those in the untreated animals, and no light bodies were observed. Therefore, YM-08310 was demonstrated histologically to have a protective effect on the parotid gland in animal experiments.
耳鼻咽喉科臨床学会の論文