子宮頸癌のLOHの臨床における意義

概要

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Cervical carcinomas develop as a result of multiple genetic alterations, and specific alterations lead to specific clinical behavior.<BR>A loss of heterozygosity (LOH), which points to a role for tumor-suppressor genes (TSGs), oncogene amplification, and point mutations are all thought to be involved, but there is as yet no complete picture of the relative role for each of these genetic changes in patients with cervical carcinomas. To play a role in tumorigenesis, both copies of a TSG must be inactivated. The loss of one allele in a chromosome region may point to the presence of a TSG in that region. Studies of LOH in patients with cervical carcinoma have also reported a high frequency of allelic deletions affecting 3p,6p,17p, and 18q.<BR>In this paper, we reported the incidence of LOH on 3p,6p,17p, and 18q in the DNA of patients with cervical cancer and assessed the impact on the clinical significance of genetic alteration in cervical cancer.
Kinki Brain Tumor Pathology Conferenceの論文