脳血管攣縮に対する Fluosol-DA の効果

概要

論文の詳細を見る
Perfluorochemicals (Fluosol-DA 20%), which is 0.1μ t in an average particle size and a high oxygen carrier, may be able to reach cerebral ischemic region and to improve its microcirculation.<BR>Sixteen patients with intracranial ruptured aneurysm which had postoperative cerebral vasospasm, were treated by the intravenous administration of Fluosol-DA between February, 1981, and February, 1982. There were 8 males and 8 females, with an average of 50.4 years (range 15 to 69 years). On the all patients who were employed 1500ml of Fluosol-DA in total, nine cases were given 500ml/day (7.1 to 11.6ml/kg) daily for three days and, seven cases were given 1000ml (16.6 to 20.8ml/kg) at the first day and 500ml (8.3 to 10.4ml/kg) at the second day.<BR>Clinical efficacy could mainly estimated by changes of consciousness level according to 3-3-9 formula and muscle testing (grade 0-5), including the findings of EEG and angiography seven days after the administration. Improvement of consciousness level and/or muscle testing, which had more than two grades, occurred in 75% of 12 cases among 16 cases. There were no side effects for the agents.<BR>It was suggested that Fluosol-DA had a beneficial effect on focal cerebral ischemia caused by vasospasm following subarachnoid hemorrhage.