Significant Correlation between Chromosomal Aberration and Nuclear Morphology in Urothelial Carcinoma
スポンサーリンク
概要
- 論文の詳細を見る
We aimed to identify whether there is any correlation between chromosomal/genetic changes, nuclear morphology and the histological grade of urothelial carcinomas of the urinary bladder. Morphometry and multicolour fluorescence in situ hybridisation (FISH) techniques were applied to 250 cells in five low-grade cases and 350 cells in seven high-grade cases of urothelial carcinoma. Compared with low-grade carcinomas, most high-grade cases showed larger and more variable nuclear size, more frequent polysomy of centromere enumeration probes (CEPs) 3, 7 and 17, and the loss of the 9p21 locus. The number of CEP signals in cells was increased as the nuclear area of the cells became larger. Cells with gains in two or more types of CEP had significantly larger nuclei than cells with normal FISH signal patterns. In conclusion, the present study indicates that there was a correlation between nuclear morphology and chromosomal/genetic changes which were related to histological grading. Thus, we show that differences in the chromosomal/genetic aberrations present in low- and high-grade tumours can affect not only nuclear morphology but also the histopathological and clinical behaviour of urothelial carcinomas.
著者
-
WATANABE Hiroshi
School of Frontier Sciences, The University of Tokyo
-
Murata Shin-ichi
Department of Human Pathology, Interdisciplinary Graduate School of Medicine and Engineering, Facult
-
Shimizu Michio
Department Of Pathology Kawasaki Medical School
-
Ueno Munehisa
Department Of Urology Biomedical Research Center Saitama Medical School
-
Seyama Atsushi
Department Of Surgery Shutoh General Hospital
-
Gotoh Yoshiya
Department Of Pathology Saitama Medical School
-
Fukuda Toshio
Department Of Cytopathology Graduate School Of Health Sciences Gunma University
-
Nakamura Masaru
Department Of Applied Chemistry Faculty Of Science And Engineering Kinki University
-
Gotoh Yoshiya
Department of Pathology, International Medical Center, Saitama Medical University
-
Shuto Masayo
School of Medical Technology and Health, Faculty of Health and Medical Care, Saitama Medical University
-
Kamada Kouichi
Department of Pathology, International Medical Center, Saitama Medical University
-
Warigaya Kenji
Department of Human Pathology, Wakayama Medical University
-
Seyama Atsushi
Department of Pathology, International Medical Center, Saitama Medical University
関連論文
- An Up-to-Date Anti-Cancer Treatment Strategy Focusing on HIF-1α Suppression : Its Application for Refractory Ovarian Cancer
- Details of the Nitech HMM-Based Speech Synthesis System for the Blizzard Challenge 2005(Speech and Herring)
- Finite Element Analysis on the Relationship between Left Ventricular Pump Function and Fiber Structure within the Wall(Bioengineering)
- Computer Simulation of Blood Flow, Left Ventricular Wall Motion and Their Interrelationship by Fluid-Structure Interaction Finite Element Method(Reviewed Papers Accepted for Publication in this Special Issue)(Special Issue on Bioengineering)
- Expression of cysLT1 and cysLT2 Receptor in Chronic Hyperplastic Eosinophilic Sinusitis
- Clinicopathological Characteristics of Esophageal Squamous Papillomas in Japanese Patients : With Comparison of Findings from Western Countries
- Comparison of the Effects of Pioglitazone and Metformin on Insulin Resistance and Hormonal Markers in Patients with Impaired Glucose Tolerance and Early Diabetes
- Intraosseous Cholesterol Granuloma of Radius Showing a Lamellar Structure on MR Images: A Case Report
- HHV8-negative primary effusion lymphoma of the peritoneal cavity presenting with a distinct immunohistochemical phenotype
- Detection of c-myc mRNA by in situ hybridization
- Differential Diagnosis of Primary Benign and Malignant Retroperitoneal Tumors
- Solitary Metastatic Malignant Melanoma of the Small Intestine : Findings Obtained during Intraoperative Enteroscopy
- Epstein-Barr virus-associated Hodgkin's disease in HTLV-I seropositive patients : A report of two cases
- Vision Based Navigation System of Autonomous Mobile Robot : (Planning of Landmark Sensing Considering Environmental Conditions)
- A Study on Wall Surface Mobile Robots : Development of Moving Mechanism for Crawler-Type Wall Surface Mobile Robots with Vacuum Pads
- Mixed papillary adenocarcinoma and transitional cell carcinoma of the uterine cervix
- P4-27 Immunohistochemical and enzymehistochemical expression of CD73 (5'-Nucleotidase) in thyroid tumor
- P2-02 Spatial Distribution Analysis of AT-and GC-Rich Regions in Nuclei Using Corrected Fluorescence Resonance Energy Transfer
- Exogenous Expression of Interferon-β in Cultured Brain Microvessel Endothelial Cells(Biochemistry/Molecular Biology)
- Expression and Visualization of a Human Interferon-β-Enhanced Green Fluorescent Protein Chimeric Molecule in Cultured Cells (Biochemistry/Molecular Biology)
- Nano Robotic Manipulation inside Electron Microscopes
- Establishment of a Human Cell Line Secreting Neuron-specific Enolase from a Primitive Neuroectodermal Tumor of the Retroperitoneal Cavity
- Effects of FR167653, a dual inhibitor of interleukin-1 and tumor necrosis factor, on adjuvant arthritis in rats
- Nonfunctioning Endocrine Tumor of the Pancreas with Extrapancreatic Growth and Cyst Formation: Report of a Case
- Differentiation and Monitoring of Cells Using a Biochip for Regenerative Medicine : Differentiation of Bone Marrow Stromal Cells and Myoblasts
- EXPRESSION OF ESTROGEN RECEPTORS AND STEROIDOGENIC ENZYMES DURING GONADAL DIFFERENTIATION IN A TELEOST FISH, TILAPIA NIROTICUS(Developmental Biology)(Proceedings of the Seventieth Annual Meeting of the Zoological Society of Japan)
- Fish 3β-Hydroxysteroid Dehydrogenase/Δ^5-Δ^4 Isomerase : Antibody Production and Their Use for the Immunohistochemical Detection of Fish Steroidogenic Tissues
- Ciliary ultrastructure in two sisters with Kartagener's syndrome
- A case of biphasic pulmonary blastoma
- Control of a Standing Wave Field Using a Line-Focused Transducer for Two-Dimensional Manipulation of Particles
- An omni-directional six-legged walking robot
- Mechanism and Control of Man-Robot Cooperative-Work-Type Manipulator
- A study on a brachiation controller for a multi-locomotion robot-realization of smooth, continuous brachiation
- Production of parathyroid hormone-related protein in two new cell lines of renal cell carcinoma
- Simultaneous production of granulocyte colonystimulating factor and parathyroid hormone-related protein in bladder cancer
- Suppression of default apoptosis in androgen-dependent cells by testosterone-mediated bcl-2 expression
- Laparoscopic treatment of retroperitoneal benign schwannoma
- A New Technique of Arteriovenous Fistula with Titanium Clip Appller
- Angiogenic factors in normal endometrium and endometrial adenocarcinoma
- Hyalinizing trabecular adenoma of the thyroid : Its unusual cytoplasmic immunopositivity for MIB1
- Regulation of Tissue-Type Plasminogen Activator(tPA)and Type-1 Plasminogen Activator Inhibitor(PAI-1)Gene Expression in Rat Hepatocytes in Primary Culture^1
- Oxyphilic cell variant of endometrioid adenocarcinoma
- Adenoid basal carcinoma of the cervix uteri : A case report
- Communication Architecture for Cellular Robotic System
- Pathology of non-Helicobacter pylori gastritis : extending the histopathologic horizons
- Primary ectranodal marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue type in the CNS
- A Case of Spindle Cell Carcinoma of the Breast-Long Survival Achieved by Multiple Surgical Treatment
- Application of Neural Network-Based Servo Controller to Position, Force and Stabbing Control by Robotic Manipulator
- Flexibility Control of Flexible Structures : Modeling and Control Method of Bending-Torsion Coupled Vibrations
- Modeling and Control of Torsional Vibrations in a Flexible Structure : Vibration, Control Engineering, Engineering for Industry
- Renal Oncocytoma Associated With Long-Term Hemodialysis
- Giant Cell-Rich Osteosarcoma Simulating Giant Cell Tumor of Bone
- Acute osteomyelitis of the patella in a child
- Small invasive ductal adenocarcinoma of the pancreas associated with lymphoplasmacytic sclerosing pancreatitis
- A Cyst of Benign Mediastinal Teratoma Demonstrating a Peculiar Development : Report of a Case
- Extravascular papillary endothelial hyperplasia of the palm masquerading as an angiosarcoma
- Nephrotic syndrome as a result of membranous nephropathy caused by renal cell carcinoma
- Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells
- Characterization of a newly established cell line derived from human adrenocortical carcinoma
- Hypercalcemia in a patient with renal cell carcinoma producing parathyroid hormone-related protein and interleukin-6
- Histopathology of the thyroid in amiodarone-induced hypothyroidism
- Inflammatory Pseudotumor of the Liver : A Case Report
- Isolated High-Purity Platinum Nanowire Growth via Field Emission from a Multi-Walled Carbon Nanotube
- Solid-pseudopapillary carcinoma of the pancreas
- Ovarian mucinous cystadenocarcinoma with malignant mural nodules
- Gastric metastasis from breast cancer : A pitfall in gastric biopsy specimens
- Fatty replacement of the pancreatic body and tail associated with leiomyosarcoma of the pancreatic head
- A Case of Noncystic Branch Duct-Type Carcinoma In Situ of the Pancreas
- Cutaneous reactive angiomatosis occurring in erythema ab igne can cause atypia in endothelial cells : Potential mimic of malignant vascular neoplasm
- Pathological evaluation of uterine leiomyomas treated with gonadotropin-releasing hormone agonist (GnRH-a) therapy : Role of mast cells and a possible mechanism of GnRH-a resistance in leiomyomas
- Application of Image Analysis with Neural Network for Plant Somatic Embryo Culture
- Stable Control of Robotic Manipulator with Collision Phenomena : Positioning of Multi-Degrees-of-Freedom Linear Manipulator
- Microchip Design and Experiment for Separation of Microbe from Continuous Sample Liquid Flow Using Optical Tweezers
- Nanoassembly of Carbon Nanotubes through Mechanochemical Nanorobotic Manipulations
- Metanephric adenoma of the kidney : Ultrastructural, immunohistochemical and lectin histochemical studies
- Flexibility Control of Solar Battery Paddles : 1st Report, A Method of Vibration and Attitude Control Based on Outputs of Solar Instrument Sensors
- Squamous intraepithelial neoplasia of the esophagus : past, present, and future
- HEMORHEOLOGIC PROPERTIES AND PLATELET FUNCTION DURING EXERCISE IN PATIENTS WITH CORONARY ARTERY DISEASE : Exercise Test : 46th Annual Scientific Meeting, Japanese Circulation Society
- Robust On-Line Frequency Identification for a Sinusoid
- Secondary tumors of the pancreas : Clinicopathological study of 103 autopsy cases of Japanese patients
- Multiple Fuzzy Controls
- Laparoscopic Cecopexy for Mobile Cecum Syndrome Manifesting as Cecal Volvulus : Report of a Case
- Laparoscopic Resection of an Ileal Lipoma : Report of a Case
- 2P1-C20 Local Stiffness Measurement of Single Cell using Nanoprobes through ESEM-Nanomanipulator System
- ERGOMETRIC EXERCISE TESTING IN ASSESSMENT OF FUNCTIONAL CAPACITY OF PATIENTS WITH CARDIAC DISEASE : Ventricular function (I) : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- DESTRUCTIVE CONSTRUCTION OF NANOSTRUCTURES WITH CARBON NANOTUBES
- Method of Autonomous Approach, Docking and Detaching Between Cells for Dynamically Recontigurable Robotic System CEBOT
- Towards a Self-organizing Multi-model System
- Hierarchical trajectory planning of redundant manipulators with structured intelligence
- Neutrophil elastase contributes to extracellular matrix damage induced by chronic low-dose UV irradiation in a hairless mouse photoaging model
- Self-organizing control strategy for group robotics
- Nanoactuation of Telescoping Multiwalled Carbon Nanotubes inside Transmission Electron Microscope
- Biopsy interpretation of colonic biopsies when inflammatory bowel disease is excluded
- Significant Correlation between Chromosomal Aberration and Nuclear Morphology in Urothelial Carcinoma
- Impact of Mid-Niigata Prefecture Earthquake on Cardiovascular Diseases
- Conversion of mono-polar to peritrichous flagellation in Vibrio alginolyticus
- Biodegradable porous sheet-like scaffolds for soft-tissue engineering using a combined particulate leaching of salt particles and magnetic sugar particles(CELL AND TISSUE ENGINEERING)
- Effect of Concanavalin A on Intracellular Calcium Concentration in Single Blood Platelets.
- Mechanism of augmentation of natural cytotoxicity by hyman beta-interferon.
- Distinctive expression of CD133 between intraductal papillary neoplasms of the bile duct and bile duct adenocarcinomas