頭頚部悪性腫瘍に対するN-CWSによる免疫療法-1-根治的治療後のsuppressive効果についてのrandomized control study (内藤儁教授退官記念論文集)

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Nocardia-CWS (N-CWS) was examined for adjuvant-immunotherapeutic effectiveness in patients with head and neck malignancies whose tumour mass has diminished after radical operation and/or radical irradiation.The evaluation of effect of N-CWS was done with comparing between the nonrecurrent rate of patients who had been injected N-CWS and that of patients who had not injected under randomized control study.The subjects comprised 36 patients who were given N-CWS injections. They completed both their therapeutic courses and subsequent 6-month or more observation periods in or before April, 1979. The control patients numbered 35 and matched for disease and severity.The rate of sufficient control, as difined by the rate of no local recurrence of tumour mass or metastasis after radical treatment in the subjects and control patients, was 75% (27/36) 71% (25/35), respectively, at 6 months; 61% (17/28) and 41% (9/22) at 12 months; and 50% (11/20) and 25% (3/12) at 18 months.The patients on N-CWS were better controlled than the reference patients by ca 20%, and these findings clearly showed the excellent immunotherapeutic effectiveness of the agent.
耳鼻咽喉科臨床学会の論文