喉頭のEpithelial Hyperplasia--臨床的ならびに病理組織学的研究

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Sixty-three cases of epithelial hyperplasia of the larynx which were reviewed in our clinic from January 1971 to December 1978. Thirty-five cases were treated surgically and examined histologically. Results obtained as follows:1. Among the patients with epithelial hyperplasia, the male was much more frequent than female. The age showed a predominance in the older group aging 50 to 60 years.2. Seventy-six per cent of the patients were smokers and 24 per cent of those were non-smokers. It was thought that smoking is one of an important factor in the etiology.3. The vocal folds were affected bilaterally in 30 cases (48%). The left vocal fold was affected 25 cases (40%) and the right was 8 cases (13%).4. Thirty-four cases were treated under endolaryngeal microsurgery, in which 8 cases were treated by irradiation therapy after surgery. In one case, mass lesion was removed under indirect laryngoscopy because of heart disease and was indicated by irradiation.5. Voice recovery was found in 24 cases (86%) subjectively. The rate of recovery of voice was markedly high in these patients.6. Seven cases in 35 cases were developed carcinoma of the larynx after microsurgery. Of this group, one died of local recurrence and one died of other cause following total laryngectomy.7. Thirteen cases in 35 cases were found cell atypia histologically. Seven cases in this group, who were developed squamous cell carcinoma from 6 months to 21/2 years following an initial treatment. In remaining 22 cases without atypia, there is no evidence of developing carcinoma up to date.8. It was proposed that the diagnosis of epithelial hyperplasia of the larynx is classified to following histological findings:I. Hyperplasia without atypiaa. without basal cell hyperplasiab. with basal cell hyperplasiaII. Dysplasiaa. low gradeb. high gradeIII. Carcinomaa. carcinoma in situb. invasive carcinomaThe cases with cell atypia have developed carcinoma to approximately a harf of them. It should be noted whether there is any development of carcinoma after an initial treatment.
耳鼻咽喉科臨床学会の論文

喉頭のEpithelial Hyperplasia--臨床的ならびに病理組織学的研究

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