超音波顕微鏡の原理と組織の物性測定への応用について : 声帯の組織を例として

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This article presents a tutorial introduction to the acoustic microscope in relation to the measurement of the mechanical property of biological tissues. The greatest advantage of the acoustic microscope is that it can provide following two features simultaneously: (1) high resolution, and (2) information on mechanical properties. As for(1), a resolution in the order of 1μm is obtained when an ultrasonic wave in the order of 100MHz is used. As for(2), in a simplest case, a reflected image conveys the information on elastic property whereas a transmitted image conveys the information on viscous property. As an example, two pictures are presented;one for a thin specimen(10μm thick)and the other for a thick specimen(2mm thick)of a human vocal fold tissue both taken by an acoustic microscope of the reflection type. The results were as follows: (a) The picture for athin specimen was similar to a transmitted image instead of a reflected image when the specimen was placed on a slide glass. (b) The picture for a thick specimen was successfully taken in reflected mode. A preliminary discussion concerning the mechanical properties of the vocal fold tissue is presented. A detailed analysis of the image in relation to the tissue property remains for future study.
社団法人日本耳鼻咽喉科学会の論文