Clinical effect of tofisopam (Grandaxin) in patients with vertigo, dizziness and/or tinnitus.

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The therapeutic effect of Tofisopam was studied in 30 patients with vertigo, dizziness and/or tinnitus. They were given oral Tofisopam 150mg daily (50mg three times a day), and the severity of their complaints was recorded before and two or four weeks after the start of treatment.The medication was effective in 63.2% of the patients with vertigo and/or dizziness, and in 66.7% of the patients with tinnitus. Psychological analysis (T. M. I.) showed a significantly better response in patients with autonomic dysfunction complaints than in those with neurosis. Significant improvement was also noted in patients with tinnitus, the frequency of which was under 2kHz.These results indicate that Tofisopam is useful in the treatment of selected patients with neurootological diseases such as vertigo, dizziness and tinnitus.
耳鼻咽喉科臨床学会の論文