Enhanced cytocidal effect by a combination of amphotericin B plus 5-FU in hybrid nasopharyngeal carcinoma cells.

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It has been demonstrated that the antifungal lipophylic polyene, amphotericin B(AMB)inhibits eukaryotic cell growth by binding to sterols and making 'holes' in cell membranes. Used at subinhibitory concentrations, it enhances penetration of other chemicals into the cells. We report here on the sensitivity to AMB of an established nasopharyngeal normal cell line:Ad cells, and of a hybrid nasopharyngeal carcinoma cell line: A2L/AH cells, produced by a cell fusion technique. A2L/AH cells were more sensitive to AMB in respect to cell growth and colony forming activity than were Ad cells. Tumor cells and normal cells were treated with AMB and the anti-cancer drug 5-FU, and their cytotoxic effect was compared. The synergistic effect on A2L/AH cells suggested that AMB enhances the effectiveness of chemotherapy in the treatment of nasopharyngeal carcinoma.
耳鼻咽喉科臨床学会の論文