減感作療法とT細胞サブセットの動態について

概要

論文の詳細を見る
House Dust has been the key subject as a main antigen in the specific immunotherapy of atopic allergic diseases, including nasal allergy and bronchial asthma, and the mechanism of therapy has been investigated and elucidated from the viewpoint of humoral immunity, especially antibodies. However, attention is being paid at present to its relation to cellular immunity, especially to the function of T-cells which play a major part in the immunity of the mechanism of effective therapy. Recently, the authors carried out a cellular immunological study of the behavior of T-cell subsets before and after house dust hyposensitization therapy, obtaining the results summarized as follows:(1) There was no difference between the white blood cell, lymphocyte and T-cell counts before and after therapy.(2) TG-cells having the receptor for the Fc fragment of IgG antibodies tended to increase in number after therapy.(3) When the treatment was effective or remarkably effective, an increase in TG-cell count was seen in many cases, and a significant increase in count was observed especially in remarkably effective cases.(4) T-cells were considered to take part in the mechanism of effective specific immunotherapy.
耳鼻咽喉科臨床学会の論文