声帯内の酸性ムコ多糖,酸性糖たんぱく質--特に加令による変化について

概要

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Acid mucopolysaccharide (AMPS) and glycoprotein consist of long chain, protein-bound polymers of high viscosity. The purpose of this study was to determine whether AMPS and glycoprotein were present in the mucosa of the vocal fold, and if so, to identify the kind of AMPS and to investigate the relationship of AMPS and glycoprotein to age.Vocal folds were obtained at autopsy from 27 cadavers aged 4-83 years, 19 males and eight females. The total amount of AMPS in the vocal fold was measured by the Dishe method. The identification of AMPS was done by cellulose acetate stripelectrophoresis and digestion by specific enzyme. Glycoprotein in the vocal fold was determined by the sialic acid TBA method.1) The AMPS in the vocal fold was hyaluronic acid in all cases.2) AMPS decreased with age (γ=-0.50), rapidly until 30 years of age and then more gradually.3) Glycoprotein also decreased with age (γ=-0.56), significantly until the age of 20 and then gradually.
耳鼻咽喉科臨床学会の論文