The Sensibility of the Bone Marrow:Electrophysiological and Histological Studies

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In this paper, several kinds of stimulation were given to the dog bone marrow and response was analyzed electrophysiologically. Histological studies of the bone marrow were also carried out.Intraosseous pressure stimulation produced response on threshold of 100-130mmHg.Intramedullary administration of chemical pain substances produced responses at the following concentrations: potassium chloride, 10-3g/ml; acethylcholine chloride, 10-7g/ml; histamine dihydrochloride, 10-6g/ml; serotonin, 10-6g/ml; bradykinine, 10-8g/ml.Ligature of the femoral artery caused reduction of intramedullary temperature, and response was obtained at thermal reduction of 0.8°-1.0°C. Infusion of epirenamine hydrochloride (10-3g/ml) or norepirenamine hydrochloride (10-3g/ml) into the bone marrow induced the thermal fall, which produced response at 0.5-1.2°C.The medullary branch of tibial nerves used for leading, comprised unmyelinated and myelinated nerve fibers mixedly in a ratio of about 6.6:1, mostly included in the category of Aδ or C fibers. End structures of nerve fibers in the bone marrow were of the simple branching or non branching type, and lacked specific endings.
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