Pathomechanism of formation of calcium pyrophosphate dihydrate crystal.
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Articular and ligamentous tissues in 20 patients with calcium pyrophosphate dihydrate (CPPD) crystal deposition disease were studied by using histological, electron probe analysis and X-ray diffraction techniques.Peculiar chondrocytes or metaplastic chondrocytes that seem to accumulate proteoglycans and inorganic pyrophosphate were seen constantly in the area of incipient formation of CPPD crystals. These cells appear to contribute formation of CPPD crystals by releasing inorganic pyrophosphate mostly from the portion showing destruction of cell membrane. The histological and histochemical findings in this study also indicate that proteoglycans play an important role in crystal growth by carrying high concentration of inorganic pyrophosphate on the crystal surfaces.
- 西日本整形・災害外科学会の論文
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