A case of adult onset idiopatic Fanconi syndrome.

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A case of adult onset Fanconi's syndrome was presented. A 45-year-old female, complaining of walking pain of the both hips, was hospitalized in our clinic on February 19, 1986. She arose from the floor "climbig on the legs" and walked swaying. She complained of hip pain on gait but passive motion of her hips was painless and the range of motion was normal. Clinically, weakness was present in the muscles of the limbs. Looser's zone in both femoral necks, diffuse bone atrophy of the pelvis and femurs were shown on radiograms. Laboratory findings revealed a feature and other examinations were made, but we could not find any findings to confirm multiple myeloma. The patient was given Shohl's solution 1-a-OH-D3 by mouth. Two months after admission, muscle weakness disappeared and serum P, serum Cl and acidosis were normalized, but alkaline phosphatase level remained elevated. Renal dysfunction was unchanged. Now she is continuing the treatment during 22 months, she has no complaint and her laboratory findings, radiological and histological findings but renal function are in normal condition. We are observing the renal function and the appearance of cause of Fanconi's syndrome because we can not abandon the possibility of multiple myeloma or macrogloburinemia.
西日本整形・災害外科学会の論文