モルモット皮膚切創モデルにおけるN-(3-Aminopropionyl)-L-histidinato zinc(Z-103)の創傷治癒促進作用

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We investigated the effects of Z-103, ZnSO4, L-carnosine and solcoseryl on wound healing by dermal incision in guinea pigs. The tensile strength, hydroxyproline contents and the value of angiogenesis (carmine contents) at the wounded site of dorsal skin were used as indices of wound healing. Z-103, given daily s.c., increased the tensile strength and hydroxyproline contents on day 4 after operation in a dosedependent manner; in particular, the effect of 10 mg/kg of Z-103 was nearly equal to that of solcoseryl at 0.5 ml/ animal. Moreover, Z-103 10 mg/kg increased the value of angiogenesis on day 3 after the operation. On the other hand, ZnSO4 and L-carnosine, components of Z-103, also similarly increased. the tensile strength and hydroxyproline contents. These results suggest that Z-103 possessed an accelera tive action on wound healing, and these effects may be due to the activity of its components, ZnSO4 and L-carnosine.