マウス実験結核症による短期化学療法のモデル実験

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Model experiments of the short-course chemotherapy was carried out using experimental tuberculosis of the conventional mice.<BR>The experimental schedule is shown in Fig. 1. As the anti-tuberculous drugs, streptomycin (SM) 1mg (40mg/kg), isoniazid (INH) 0.3mg (12mg/kg), rifampicin (RFP) 0.3mg (12mg/kg) and pyrazinamide (PZA) 2mg (80mg/kg) were employed daily. Experimental groups were divided into thirteen as shown in Fig. 1. Mice were treated for 8, 12 or 24 weeks from the fourth week after challenge with the virulent tubercle bacilli, Kurono strain.<BR>Control groups were set for each treatment group at the beginning and end of chemotherapy and at the end of experiment.<BR>The negative rate of tubercle bacilli in vivo during chemotherapy with the combination of SM, INH and RFP and the relapse were shown in Fig. 2. By chemotherapy for more than 8 weeks tubercle bacilli in lungs and spleens converted to negative completely. Bacteriological relapse was observed, however, in 60% of cases treated with 8 weeks chemotherapy, and 40% in 12 weeks chemotherapy and no relapse was found in 24 weeks chemotherapy. The negative rate of tubercle bacilli in vivo during chemotherapy with the combination of SM, INH and PZA and the relapse were shown in Fig. 3. If treatment is terminated after 8 weeks, the relapse was seen in 80%. Even with 12 weeks chemotherapy, the relapse was found in 100%. The negative rate of bacilli in vivo during chemotherapy with the combination of SM, INH, RFP and PZA and the relapse were presented in Fig. 4. In this case the negative rate after 8 weeks chemotheraphy was 80%, and no relapse was found after terminating chemotherapy. By 12 weeks chemotherapy the negative rate became 100%, and no relapse was observed. Number of bacilli in bacteriologically relapsed cases was much samller than the untreated control in each group as shown in the following tables.
日本結核病学会の論文

著者

豊原希一
結核予防会結核研究所

マウス実験結核症による短期化学療法のモデル実験

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