1. 抗酸菌の分類とその鑑別, 同定

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A review was made of the following points out of consideration that it would be of great clinical and bacteriological significance to arrange and classify genus Mycobacterium, establish an identification scheme and elucidate its relationship with diseases in man. Arrangement and classification of recognized species by numerical analysis enabled the place ment of many species. It made possible the establishment of a classification system which covered most of the genus Mycobacterium. The development of such a system had been rather delayed as compared to those for other bacteria. It is needless to say that the final decision on the classification of recognized bacteria should be made on the basis of an international agreement. Of the various properties available for identification, 26 were selected, and by using an appropriate combination, it was possible to identify almost all mycobacteria. Diagnosis was made of diseases in 12 patients caused by mycobacteria other than tubercle bacilli, in other words“ atypical mycobacteria” such as Mycobacterium kansasii, M. scrofulaceum and M. gordonae, M. intracellulare, M. chelonei and M fortuitum. Further, a study to determine the origin of “ atypical mycobacteria” revealed that M. fortuitum is heavily distributed in our natural environ ment, and that part of the source of M. intracellulare may also be found in nature. As a member of the Mycobacteria Classification Committee of the Japanese Society for Tuberculosis, I participated in the drafting of the identification scheme for mycobacteria in clinical material, and also the subsequent revision. A study was made of the significance of the pathogenicity of these bacteria on experimental animals as a means of identifying mycobacteria. Disease states induced by intravenous injections of 107 viable units of mycobacteria into mice were helpful in identifying M. kansasii, M. marinum, M. chelonei subsp. abscessus and M fortuitum while intravenous injections (10mg) intorabbits were useful in analyzing M. avium-M. intracellulare complex. Through serological studies on mycobacteria, my associates and I were successful for the first time in developing fluorescent antibody techniques for mycobacteria and found that this method could be used for differential identification and that agglutination reaction was an effective means for differentiation of M. avium and M. intracellulare.
日本結核病学会の論文

1. 抗酸菌の分類とその鑑別, 同定

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