リポ多糖,天然リピドAおよび合成リピドAのマウスB細胞株,CYG34およびCYG101に対する増殖抑制作用

概要

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Re-mutant lipopolysaccharide (Re LPS) of Salmonella minnesota profoundly inhibited the growth of murine B-cell lines, designated CYG34 and CYG101, established from long term bone-marrow culture. When CYG101 cells were cultured together with Re LPS at concentrations of 2-100μg/ml, the cell proliferation was dose-dependently suppressed. Re LPS hardly or slightly affected the growth of a murine T-cell line, BW5147, pre-B cell lines, 70Z/3 and CYG 8, and a myeloma cell line, X63Ag8. S-form LPS of Escherichia coli and S. typhimurium, Re-mutant LPS of S. minnesota and natural lipid A of E. coil, S. typhimurium and S. minnesota also inhibited the growth of CYG101 cells. However, degraded polysaccharide of S-form LPS of S. typhimurium did not inhibit the cell growth. Synthetic compounds 406, corresponding to a biosynthetic disaccharide lipid A precursor, and 506, corresponding to lipid A of the E. coli type, also inhibited the growth of CYG101 cells. These results suggest that the growth inhibition of cell lines by LPS is selective or specific to the cell line and that the lipid A portion of LPS is involved in this growth inhibition. Double acyl groups of lipid A may not play any role in the inhibition of cell growth.
日本細菌学会の論文