Effects of Soy Oligosaccharides on Plasma and Cecal Isoflavones, and Cecal Enzyme Activities in Mice

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This paper studies the effects of soy oligosaccharides on plasma and cecal isoflavones and floral enzyme activities in adult mice. The isoflavones used in this experiment were daidzein and genistein. Male 6-wk-old mice were fed a soy oligosaccharide-isofla-vone (SOT) diet or cellulose-isoflavone (CEI) diet for 10 d. Plasma and cecal isoflavones were analyzed by HPLC, and cecal bacterial β-glucosidase and β-glucuronidase activities were also measured. The plasma genistein concentration was significantly higher in the SOT diet group than in the CEI diet group, but no significant difference was observed in plasma daidzein concentration between the two dietary groups. The total amount of cecal isoflavones existing as aglycone were significantly greater in the SOT diet group than in the CEI diet group, and both cecal β-glucosidase and β-glucuronidase activities were significantly higher in the SOT diet group than in the CEI diet group. These results indicate that soy oligosaccharides have an impact on the metabolic activity of intestinal microflora, plasma concentrations of isoflavones, and amount of isoflavones in the intestine. The present study suggests that ingestion of soy oligosaccharides may influence the effect of dietary isoflavones on the host.
財団法人学会誌刊行センターの論文
2003-06-01