先天性鼻咽腔閉鎖不全症における軟口蓋の組織学的所見-いわゆる粘膜下口蓋裂について-

概要

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This study was carried out to investigate the histological characteristics of the soft palate in three patients with congenital velopharyngeal incompetence. These patients were diagnosed as type Ia congenital velopharyngeal incompetence classified by cephalometric radiography with contrast media. The tissues examined consisted of the medial zone of the soft palate excised from the three patients and seven normal cadavers. These specimens were sectioned successively at two-or three-millimeter intervals on the frontal direction. The medial zone of the soft palate in all patients were noted macroscopically to be thinner than those of the control group. Histologically, fewer muscle fibers, more fibrosis of the interstitum and misdirection of fibers were found to varying degrees in the three patients compared with the normal cadavers.
社団法人日本口腔外科学会の論文