口腔領域の顆粒細胞腫の臨床的, 病理学的検討

概要

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Granular cell tumors are characterized by acidophillic granules in the cytoplasm. The histogenesis of this lesion is still a matter of controversy.<BR>Four cases of granular cell tumors, including one case of congenital epulis, are presented and investigated pathologically to determine the histogenesis. Histochemically, in all of these cases, intracytoplasmic granules were faintly positive in the PAS reaction, but negative in the Alcian-blue reaction, the Sudan III reaction, and the Kliiver-barrera and Bodian reaction. Immunohistochemically, two cases were positive and two cases were negative in the antisera against S-100 protein reaction. On ultrastructual evidence, the axon-like structure was found in one case, and a myelinic structure was found in all cases.<BR>According to these results, neurogenesis of granular cell tumors was suggested in three of the four cases.
社団法人日本口腔外科学会の論文