低出力炭酸ガスレーザーによる接合皮膚の創傷治癒

概要

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The following experiments were performed to examine the effect of low-output CO2 laser on wound healing process. Two wounds, incised 2cm in length, were created on the back of rat. One of the wounds was sutured for control group, the other was closed by irradiation of low-output CO2 laser. Hydroxyproline contents were spectrophotometrically determined by Edwards' method, and water contents were estimated at the same time. Histological findings were obtained after staining with hematoxylin and eosin. The results were as follows. On the first day after 200m W irradiation, degenerated layer of tissue and inflamatory response on the surface of wound were observed. On the first day after suture, necrosis and inflamatory response were found. Until 7 experimental days, hydroxyproline contents showed a higher level in irradiated group than in control group. Water contents of two groups varied near the same way. There were few differences in histological findings between irradiated group and control group. In the incised wound, heat stimulation by laser irradiation promoted collagen synthesis and hastened healing.
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