Experimental studies on the effect of low energy CO2 laser on wound healing. The effect on the healing of full thickness skin defect.:The effect on the healing of full thickness skin defect
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The following experiments were performed to examine the effect of low-power density CO<SUB>2</SUB> laser on wound healing process.<BR>1.The temperature alteration of normal rat dorsal dermi irradiated by CO<SUB>2</SUB> laser, was measured by cromel-almel thermo-couple.<BR>2.The healing of full thickness skin defects, produced in rat's dorsums and irradiated by low-power density CO<SUB>2</SUB> laser was examined by the following procedures.<BR>(1) Wound area was arithmetically measured daily.<BR>(2) Hydroxyproline content was spectrophotometrically determinedby Edward's method, and water content was determined at the same time.<BR>(3) Histological findings were obtained after staining with hematoxylin and eosin.<BR>The results were as follows.<BR>1.Rise of skin temperature was related to power density and irradiation time.<BR>2.The wound areas of irradiated groups reduced more than those of control group at 3-7 experimental days.<BR>3.At 4-14 experimental days, the hydroxyproline contents of the wounds increased more in irradiated groups than in control group.<BR>4.The wounds water content decreased and returned to normal level faster in irradiated groups than in control group.<BR>5.Histological findings of rat's dorsal dermis suggested that the wounds of irradiated groups healed swifter than those of control group, and the arrangement of collagen fibers were more well-ordered in irradiated groups than in control group.<BR>6.Low-power density CO<SUB>2</SUB> laser had thermal effects, and these effects activated collagen synthesis in the early phases of wound healing.
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- Experimental studies on the effect of low energy CO2 laser on wound healing. The effect on the healing of full thickness skin defect.:The effect on the healing of full thickness skin defect