エリスロポエチンを用いた液状保存貯血式自己血輸血の臨床応用

概要

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High-volume homologous blood transfusion are often used in oral and maxillofacial surgery. However, homologous blood transfusion involves risks such as aquired immunodeficiency syndrom (AIDS) and graft versus host disease (GVHD). Autologous blood transfusion eliminates these risks. However, large volmnes of autologous blood transfusion can cause severe anemia before surgery. Recombinant human erythropoietin (EPOCH) has been shown to enhance erythropoiesis. We therefore decided to take 400ml of blood for autologous transfusion once weekly for 3 weeks while administering EPOCH. 1) Seventeen patients with jaw deformities (male: 5, female: 12) received EPOCH while donating blood for autologous transfusion. 2) The mean total volume of blood collected amounted to 1, 082.4 ± 168.9ml. 3) 6000 units of EPOCH were given three times weekly for 3 weeks prior to surgery. 4) RBC, hemoglobin and serum Fe increased rapidly to nomal levels. 5) No adverse effects were observed. There were no abnomal fluctuations in liver function. We consider this method to be safe and effective.
社団法人日本口腔外科学会の論文