口腔癌を含む多重癌18例の検討

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Multiple cancer may develop independently in one organ or double cancer may develop separately in different organs. Both types of cancer are collectively referred to as multiple primary cancer. In this study, we reviewed a series of patients with multiple primary cancer treated in our department. Here, we report the results.<BR>In the 12-year period from January 1980 to December 1991 we treated 139 patients with malignancy. Among these patients we studied 18 cases of multiple primary cancer including 4 cases of triple cancer and 2 cases of multiple cancer of the oral cavity. The patient consisted of 14 males and 4 females.<BR>Simultaneous occurrence refers to cases in which the period from the primary to secondary cancer is less than 6 months, and heterochronous occurrence refers to cases in which this interval is 6 months or longer. Only one case occurred simultaneously, and the others occurred heterochronously. Oral cancer developed in association with cancer of other organs including the oropharynx in 3 patients, the esophagus in 3, the stomach in 3, the colon and rectum in 2, the prostate in 2, the breast in 2, and the thyroid in 1. Thus 81.3% of the cases were associated with the gastrointestinal tract (13 patients) and oral multiple cancer was observed in 2 patients. In addition, 10 patients with primary cancer and 8 patients with secondary cancer visited our department. The outcome of 18 patients showed 6 survivors (33.3%) and 12 deaths (66.7%). Out of 6 survivors, 5 patients completed treatment without tumor recurrence and one patient with triple cancer is still bearing a tumor. Out of 12 deaths, 9 died due to primary disease 9 died due to unknown causes. The 9 patients who died due to primary disease consisted of one with double cancer who died of primary cancer, 5 with double cancer who died of secondary cancer, and 3 with triple cancer who died of an uncontrollable tertiary cancer.(Although one patient with triple cancer is surviving with a tumor).<BR>In conclusion, in the diagnosis, treatment, and follow-up of oral cancer, the occurrence of double cancers of other organs, in particular the gastrointestinal tract, should be born in mild and patients with such cancers should be observed carefully in close association with other medical departments.

口腔癌を含む多重癌18例の検討

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