Oral Administration of Ethyl Acetate-Soluble Portion of Terminalia chebula Conferring Protection from Streptozotocin-Induced Diabetic Mellitus and Its Complications
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概要
- 論文の詳細を見る
Terminalia chebula has been widely used in India as a folk medicine. This study investigated the in vivo anti-hyperglycemia and anti-diabetic complication effects of the EtOAc-soluble portion of ethanolic extract of T. chebula fruit (EETC) containing 29.4% chebulic acid. Rats were divided into non-diabetic, untreated diabetic and diabetic groups. Streptozotocin (40 mg/kg body weight (BW))-induced diabetic rats were orally administered the aminoguanidine (100 mg/kg BW), high dose (500 mg/kg BW; HEETC) and low dose (100 mg/kg BW; LEETC) for 13 weeks. HEETC administration reduced the levels of blood glucose and serum lipids, decreased malondialdehyde concentrations of serum and thoracic aorta in diabetic rats, and significantly improved serum biochemical values and the pathomorphological changes of the liver and kidney in diabetic rats. Also, HEETC decreased the advanced glycation end products (AGEs) distribution in testis seminiferous tubules. Therefore, HEETC has a merit to be a potent candidate to control glycemic and diabetic complications.
- 公益社団法人 日本薬学会の論文
著者
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Kim Ji-hoon
Division Of Electrical Engineering The School Of Electrical Engineering And Computer Sciences Korea
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LEE Kwang-Won
Division of Food Bioscience & Technology, College of Life Science & Biotechnology, Korea University
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Hong Chung-Oui
Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea Univer
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Koo Yun-chang
Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea Univer
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Kim Su-Jung
Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea Univer
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Kim Ji-hoon
Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University
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Koo Yun-chang
Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University
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Lee Kwang-Won
Division of Food Bioscience and Technology, College of Life Sciences and Biotechnology, Korea University
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Kim Ji-Hoon
Division of Cardiology, Department of Internal Medicine, Catholic University of Korea
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