ニクズク末に含まれるphenylpropanoidsのカイコ幼虫に対する成育阻害作用

概要

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During the course of a screening search for biologically active substances to insects, it was found that nutmeg, a seed kernel of Myristica fragrans Houtt., inhibited the growth of silkworm larvae, Bombyx mori L. In this experiment the biological effects of nutmeg and phenylpropanoids isolated from the seed(1, 2) were examined. These materials were mixed with artificial diets and orally administered to fourth or fifth instar larvae of silkworm. As the result the following informations were obtained: 1) When fourth instar larvae were fed on diets containing nutmeg, the growth of the insects was inhibited with the increase in the dosage (Tables I and II). At a dosage of 3%, a 100% mortality was observed in fourth instar larvae 5 days after third molting, while at a 1% dose some of the larvae spinned cocoons without fourth larval molting. 2) Among the monomeric phenylpropanoids tested here (Table III), myristicin showed the strongest growth inhibitory activities. 3) Of the dimeric phenylpropanoids, compounds III and V showed the strongest activities (Table IV). III revealed an antifeeding effect on fourth instar larvae, whereas V possessed a stomach toxicity to cause a 90% mortality at a dose of 100 ppm.
社団法人日本農芸化学会の論文