Investigation of endogenous prostaglandins on 1,2-dimethylhydrazine induced colonic cancer in rats. Inhibition of proliferation in colonic cancer with indomethacin treatment.:Inhibition of Proliferation in Colonic Cancer with Indomethacin Treatment

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In order to know the role of endogenous prostaglandins (PGs) in 1, 2-dimethylhydrazine (DMH) induced colonic cancer of rats, the effect of indomethacin (IND), which inhibits biosynthesis of PGs, on the promotion of the tumors was studied. On the 29th week of the treatment, the animals were sacrificed 48 hours after final administration of IND, and the resected colon was subject to the morphologic study and determination of PGs. By administering IND in the initial period of 16 weeks, the incidence of colonic cancers did not decrease significantly. On the other hand, the sum of the size of colonic cancers decreased distinctly during the latter period of 12 weeks by administration of IND. The levels of PGE in non-cancerous colonic mucosa decreased obviously in animals given IND in the latter 12 weeks. But PGE levels of colonic cancers did not change. There were no regularities of the PGF2α levels in either non-cancerous mucosa nor cancer. The results suggests that the increase of the PGE levels promote proliferation of colonic cancer in DMH treated rats.
財団法人日本消化器病学会の論文