Macroscopic, pathological and stereomicroscopic studies of experimental gastric cancers in dogs.

概要

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In order to investigate the fine abnormal mucosal changes of microcancer and type IIb early cancer of the stomach, we induced gastric lesions in six mongrel dogs by oral administration of ENNG solution. As a result of macroscopic and histological examination, canine cancers were similar to those of human ones in major part.As a consequence of stereomicroscopic observation in 54 lesions, type I, type IIb and shallow type IIc early cancers were considered as the most benefical objects of stereomicroscopic examination. Especially, the latter two types of early cancers showed characteristic findings according to the histological types of them. In differentiated adenocarcinomas, the irregular foveolar pattern, which was differed from that of intact mucosa, was observed. In undifferentiated adenocarcinomas, the mucosal pattern was similar to that of the surrounding intact mucosa, but various sizes of enlarged and extended areola were demonstrated. It was considered that these stereomicroscopic findings reflected the histological cancerous invasion respectively.These results are considered to be valuable for the progress of clinical diagnosis of gastric cancer by means of magnifing examinations.
財団法人日本消化器病学会の論文