肝胆道疾患における糞便中胆汁酸排泄量と脂肪消化吸収不良との関係について

概要

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In order to study on abnormality of fat absorption from intestine in patients with hepatobiliary diseases, fecal bile acid, serum bile acid and fecal fat were determined in 13 normal subjects and 19 patients (liver cirrhosis, primary biliary cirrhosis (PBC) and cholestasis). The results were as follows:1. The mean values of daily fecal excretion in cirrhosis, PBC, and cholestasis were 157, 343 and 124gm respectively. These data were not significantly different from controls (149gm).2. In all patient groups a significant increase of fecal fat, a remarkable decrease of fecal bile acid and elevation of serum bile acid were detected. Then, there was a significantly negative correlation between fecal fat and fecal bile acid excretion. When excretion of fecal bile acid was decreased below 30mg per day (one-tenth of that in controls), chemical steatorrhea in hepatobiliary diseases was always noted.Therefore, we concluded that chemical steatorrhea in hepatobiliary diseases could be induced due to the reduced amonuts of bile acid in intestine.