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This experimental study was carried out to clarify the change of pancreatic endocrine function in acute pancreatitis. Male Donryu rats used in the studies were divided into 2 groups, consisting of a group of rats with acute pancreatitis that was induced by Block's method, and a group of rats with simple laparotomy that served as control. And both groups were studied on insulin and glucagon levels in pancreas tissue, protein synthesis, that was examined by the uptake of labeled amino acid, of isolated islets of Langerhans obtained by the collagenase digestion method, and release of insulin and glucagon from isolated islets.Insulin and glucagon levels of the pancreas tissue in the rats with acute pancreatitis were significantly lower than that in the control rats. The uptake of labeled amino acid in isolated islets decreased gradually in the rats with acute pancreatitis. And the release of insulin from isolated islets reduced at the 72th hr after acute pancreatitis started. On the other hand, the release of glucagon from isolated islets reduced at the 6th hr.These findings, that were observed in the rats with acute pancreatitis, showed that there was . a reduction of synthesis and secretion function in endocrine cells of the pancreas, and suggested that the damage of A cells occurred more rapidly than that of B cells.
財団法人日本消化器病学会の論文