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Development of gastric cancer was experimentally investigated in conditions of anacidity and hyperacidity of gastric juice. By method of injesting drinking water containing MNNG (N-methyl-N'-nitro-N-nitrosoguanidine) in concentration of 50mg/l for 20 weeks, gastric cancer whose invasion was limited to the mucosa of glandular stomach in wistar male rats had been established. The animals were divided into two groups; one was fundectomized and showed anacidity of gastric juice and the other was simply laparatomized, showing normoacidity. At the 50th week after beginning to intake MNNG, the incidence of further development of gastric cancer which was defined as being a tumor invading the deeper layer beyond the submucosal layer, was 67% (20/30) in the group of rats with anacidity and 20% (9/44) in that with normoacidity.Other rats with mucosal cancer of glandular stomach prepared by the same method were grouped into two. One group rats which were injected 2000γ/kg b.w. of AOC-tetragastrin in depot form subcutaneously once daily for 10 weeks. The other rats were injected with oil using the same technique mentioned above. The incidence of occurrence of gastric cancer at the 50th week after the beginning of the experiment was 29% (7/24) in the group with AOC-tetragastrin injection and 25% (8/32) in that with oil injection. The size of tumors were 5±3mm in maximum diameter in the group with AOC-tetragastrin injection and 19±10mm in the group with oil injection. The depth of the tumor invasion was shallower in the group with AOC-tetragastrin injection than in the group with oil injection.And so, it is concluded that anacidity of gastric juice promotes development of gastric cancer and hyperacidity inhibits it.
財団法人日本消化器病学会の論文

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