Experimental study on the prolonged antigenic stimulation and histamine in chronic liver injuries

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Role of autoallergic mechanism on the chronicity of liver disorders with special referenceto histamine, which is said to be one of the chemical mediators and vaso-active amines andplays a large part in antigen/antibody reaction, was investigated experimentally.Under the administration of homologous liver antigen with histamine to rabbits, liverinjury closely resembling chronic active hepatitis could be developed which progressed intoliver cirrhosis with pseudolobulus formation. Furthermore, liver cell carcinoma, whichmetastasized to the lungs, kidney and spleen, was demonstrated in one animal and bile ductcarcinoma in one animal and epithelial hyperplasia of bile ductules in one animal. Thesefacts suggest that autoallergic mechanism may participate in the development of chronicliver injuries and perpetual antigenic stimulation with resultant hyperhistaminemia has alarge role on the initiation and progression of malignant tumors and the role of histamineshould never be ignored.
財団法人日本消化器病学会の論文