MONOCLONAL IMMUNOGLOBULINS IN GASTRIC CANCER:Immunological Aspects of Correlation with M-Components and Cancer

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Myelomas and Waldenstrom's macroglobulinemias have monoclonal immunoglobulins produced by single clone of neoplastic immunoglobulin synthesizing cells in the bone marrow or lymphoid tissues. And monoclonal immunoglobulins have also been found in serum obtained from patients with non-lymphoid neoplasms or inflammatory diseases and from healthy persons, especially those over the age of 60. The association of M-components and plasmocytosis has been occasionally found in patients with carcinomas, described by Waldenström. Isobe and Osserman noted M-components in 128 patients with non-reticular neoplasms, analyzed 806 cases with such proteins. In thier report, these M-components were found most often in patients with carcinoma of the rectosigmoid, prostate and breast. In our report, these M-components were markedly found in patients with gastric cancer (16 cases). On these 16 cases, immunological and histological analysis was reported and the relationship between the presence of the M-components in the serum and histological aspects around the carcinomas was discussed.
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