Studies on proliferation and differentiation of fundic mucosa in rats:trophic effect of AOC-tetragastrin oil suspension and insulin Novo lente

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1) Dose responses of acid secretory capacity by AOC-tetragastrin (oil suspension) and insulin (Novo lente) were examined in Schild's rats. Optimal dosis of AOC-tetragastrin and insulin were 1mg per day and 2 u. per day respectively.2) After administration of AOC-tetragastrin (oil suspension 1mg per day for 21 days) and insulin (Novo lente 2 u. per day for 21 days), 3H-thymidine 250μCi was injected i.p. 30 minutes before killing. Labeling index of generative cells in the fundic mucosa was 28.6% in AOC-tetragastrin administration, 27.2% in insulin and 14-17% in control.3) AOC-tetragastrin (oil suspension 1mg per day) and insulin (Novo lente 2 u. per day) were administered in rats for 35 days. AOC-tetragastrin caused marked increases in the volume, in the total parietal cell population, ands light increases in the total chief cell polupation of the fundic mucosa. Insulin caused increases in the total chief cell population of the fundic mucosa, but had no effect on the total parietal cell population. In the administration of AOC-tetragastrin together with insulin, the total parietal cell population was very much the same as that in AOC-tetragastrin only, and the total chief cell population was very much the same as that in insulin only.
財団法人日本消化器病学会の論文